Xospata Details: Adverse Reactions, Dosage Prescription, Price, Alongside Additional Information
Xospata, a brand-name prescription medication, has been approved by the Food and Drug Administration (FDA) to treat a specific form of acute myeloid leukemia (AML) in adults. This treatment is a targeted therapy, specifically a tyrosine kinase inhibitor (TKI), and is used for AML that has returned or did not respond to other treatments, and where the cancer cells have an FMS-like tyrosine kinase 3 (FLT3) gene mutation.
It's essential to note that Xospata should not be taken if you're pregnant or planning to become pregnant. Women should take a pregnancy test one week before starting Xospata treatment. Furthermore, Xospata is not currently available in generic form and is usually only available through specialty pharmacies, as it is a specialty drug.
Xospata should be taken according to the doctor's instructions, once a day, and can be taken with or without food. However, the medication comes with potential side effects, including changes in liver function tests, joint or muscle pain, tiredness, fever, pain or sores in the mouth or throat, swelling of arms or legs, rash, diarrhea, shortness of breath, nausea, cough, constipation, eye problems, headache, dizziness, low blood pressure, vomiting, and decreased urination.
More severe side effects from Xospata can include posterior reversible encephalopathy syndrome (brain swelling), abnormal heart rhythms, and pancreatitis. If you experience severe stomach pain with or without nausea and vomiting, it's crucial to inform your healthcare provider immediately.
Women should use birth control while taking Xospata and for at least six months after their last dose. Men should also use birth control (such as condoms) while taking Xospata if their female sexual partner can become pregnant. It's vital to do this even if the female is using birth control, too. Men should keep using birth control for at least four months after their last dose of Xospata.
St. John's wort can decrease how well Xospata works, while some medications can slow down the body's ability to break down Xospata, potentially increasing the number or strength of side effects. Examples include certain antimicrobials, HIV medications, heart medications, antidepressants, and other medications. On the other hand, antiseizure medications and other medications can increase the body's ability to break down Xospata, potentially decreasing how well it works.
Grapefruit or grapefruit juice should be avoided while taking Xospata as they can interfere with how the drug breaks down in the body. Xospata and alcohol may not interact, but heavy alcohol use may cause pancreatitis, a serious side effect that can also occur when taking Xospata. Therefore, it is recommended to avoid heavy drinking while taking Xospata.
A clinical study compared Xospata to certain kinds of chemotherapy and looked at complete remission. People who took Xospata also stayed in remission longer (by about 13 months) and lived longer (by about four months) than people who received chemotherapy. If you have AML, you should be tested to see if you have the FLT3 gene mutation, as a test to check for this mutation was approved by the FDA in 2018.
In conclusion, Xospata is a targeted therapy used to treat a specific form of acute myeloid leukemia in adults. It's crucial to follow the doctor's instructions regarding its use, and to be aware of potential side effects. If serious side effects occur, it's essential to inform your healthcare provider promptly.
Xospata is a tyrosine kinase inhibitor (TKI) medication used specifically in adults to treat a certain form of acute myeloid leukemia (AML) with an FMS-like tyrosine kinase 3 (FLT3) gene mutation. This drug is a targeted therapy and is not available in generic form, usually only available through specialty pharmacies.
The medication should be taken once a day, as directed by the doctor, and could be taken with or without food. Potential side effects include changes in liver function tests, joint or muscle pain, tiredness, and diarrhea, among others.
More severe side effects could include posterior reversible encephalopathy syndrome (brain swelling), abnormal heart rhythms, and pancreatitis. Women should use birth control while taking Xospata and for at least six months after their last dose, while men should use birth control too, if their sexual partner can become pregnant.
Grapefruit or grapefruit juice should be avoided while taking Xospata as they can interfere with how the drug breaks down in the body. A clinical study showed that people who took Xospata stayed in remission longer and lived longer than those who received chemotherapy, so if you have AML, you should be tested for the FLT3 gene mutation.
