Hazards for Pregnant Women and Women Aiming to Conceive
Users of blockbuster weight loss medications advised to employ reliable birth control methods
Weight loss and diabetes management drugs known as GLP-1 receptor agonists, like Ozempic, Wegovy, Saxenda, Victoza, and Mounjaro, could be risky for pregnant women and those trying to conceive. The main issues are:
- Scant Safety Data: The safety of these drugs during pregnancy remains unclear due to a lack of human studies. Animal research indicates possible fetal deformities [1][5].
- Pregnancy Incidences: Strange pregnancy reports have surfaced in the UK regarding these medications, such as Mounjaro [3].
- Contraceptive Efficiency: Mounjaro may weaken the effectiveness of oral contraceptives, particularly in heavier individuals, raising unintended pregnancy risks [3].
Recommendations
To address these concerns, the UK's health authorities offer these guidelines:
- Postpone Conception: Avoid conceiving while on GLP-1 receptor agonists and for a while after stopping them (two months for semaglutide and one month for tirzepatide) [2].
- Dependable Contraception: Employ efficient contraception, such as condoms or implants, particularly within the initial four weeks of treatment or following a dosage boost [3].
- Medical Guidance: These medications should only be administered under a healthcare professional's guidance to ensure secure use and minimize risks [3][5].
- Reporting Side Effects: Any side effects should be reported through the Yellow Card scheme to collect safety data [3].
Women planning pregnancy or currently pregnant should avoid using GLP-1 receptor agonists such as Ozempic, Wegovy, Saxenda, Victoza, and Mounjaro due to lack of clear safety data and potential risks during pregnancy. Effective contraception should be employed during the initial four weeks of treatment or following a dosage boost, as these medications may weaken the effectiveness of oral contraceptives.
