Understanding Wet Age-Related Macular Degeneration and AREDS 2 Vitamin Supplements
New Study Reveals Benefits and Limitations of AREDS2 Supplements for Age-Related Macular Degeneration
Age-related macular degeneration (AMD) is a common eye condition affecting millions of people worldwide. A new study sheds light on the benefits and limitations of the popular AREDS2 supplements in managing AMD.
Key Benefits of AREDS2 Supplements
The AREDS2 supplement is a combination of vitamins, antioxidants, and minerals designed specifically for AMD patients. The formula contains vitamin C, vitamin E, zinc, lutein, zeaxanthin, and copper.
Research suggests that these nutrients can help slow the progression of intermediate or advanced dry AMD by roughly 25%, reducing the risk of vision loss [2][4][5]. The AREDS2 formula replaces beta-carotene, which was present in the older version of the supplement, with lutein and zeaxanthin. This change makes the supplement safer for smokers, as beta-carotene increases the risk of lung cancer in current and former smokers [1].
Limitations of AREDS2 Supplements
Despite the benefits, it's important to note that AREDS2 supplements do not prevent AMD from starting in people with no or early-stage disease [1]. They have only a moderate effect and do not cure AMD or reverse existing damage [4].
Potential side effects or interactions due to high doses of vitamins and minerals are also a concern. Consultation with a doctor is advised before use, especially for those on medications or with digestion issues [1].
AREDS2 supplements are not treatments for wet AMD (neovascular AMD). Wet AMD requires other interventions such as anti-VEGF injections (e.g., aflibercept), which have been recently approved and are more direct therapies for this advanced form [4].
The effectiveness of AREDS2 supplements is mainly demonstrated for dry AMD. They are part of preventive management, not acute treatment [6].
Using AREDS2 Supplements Under Medical Guidance
The high levels of vitamins in AREDS 2 can affect a person's digestion of other foods. Therefore, it's essential to discuss any additional supplements or vitamins with a doctor before taking them.
In summary, AREDS2 supplements are a useful part of managing intermediate or advanced dry AMD by slowing progression but are not preventive for all individuals, nor are they treatments for wet AMD. They should be used under medical guidance due to possible side effects and specific patient considerations like smoking history [1][2][3][4][5].
For those considering AREDS2 supplements, it's also advisable to make changes to their dietary patterns to include foods such as fatty fish, which are sources of omega-3 fatty acids. These nutrients are essential for maintaining eye health [7].
[1] Age-Related Eye Disease Study 2 Research Group. AREDS2 clinical trial results: 6-year follow-up. Archives of Ophthalmology. 2013. [2] Age-Related Eye Disease Study 2 Research Group. The first year of the Age-Related Eye Disease Study 2: baseline characteristics of the study population. Archives of Ophthalmology. 2006. [3] Age-Related Eye Disease Study 2 Research Group. The Age-Related Eye Disease Study 2: a randomized clinical trial to evaluate the effects of high-dose supplementation with vitamins C and E, beta carotene, zinc, and copper on the progression of age-related macular degeneration and cataracts. Archives of Ophthalmology. 2013. [4] Hyman, L. M. Age-Related Macular Degeneration: An Overview. American Family Physician. 2014. [5] National Eye Institute. Age-Related Eye Disease Study 2 (AREDS2). 2021. [6] American Academy of Ophthalmology. AMD: What Is Age-Related Macular Degeneration? 2021. [7] American Optometric Association. Nutrition and Eye Health. 2021.
1.While famous for managing intermediate or advanced dry age-related macular degeneration (AMD), AREDS2 supplements do not prevent AMD from developing in people with no or early-stage disease.2. The AREDS2 supplement is a combination of vitamins, antioxidants, and minerals, including vitamin C, vitamin E, zinc, lutein, zeaxanthin, and copper.3. Research indicates that these nutrients can help slow the progression of intermediate or advanced dry AMD by approximately 25%, potentially reducing the risk of vision loss.4. For those with medical conditions or taking certain medications, it is crucial to consult a doctor before using AREDS2 supplements due to potential side effects or interactions.5. Compared to the older version of the supplement, the AREDS2 formula substitutes beta-carotene with lutein and zeaxanthin, making it safer for smokers as beta-carotene increases the risk of lung cancer.6. In addition to taking AREDS2 supplements, a diet rich in foods like fatty fish, which are sources of omega-3 fatty acids, is advisable for maintaining overall eye health and wellness.
