Transforming a Lab-Based Research Proposal into a Virtual Research Endeavor
In the world of bioengineering, the ongoing COVID-19 pandemic has necessitated a shift towards remote research. A researcher at Princeton University, for instance, found themselves conducting a project investigating DNA damage in persister subpopulations of E.Coli cells from their home.
The researcher's project was lab-heavy, involving treating cells with antibiotics and DNA damaging agents. To make predictions and test conditions for their research, they leveraged MATLAB programs and simulations. This approach allowed them to continue their work despite the limitations of remote research.
However, conducting laboratory research remotely comes with its own set of challenges. For instance, the inability to physically conduct experiments can be a significant hurdle. To overcome this, the researcher turned to virtual laboratory tools. These tools enabled them to conduct lab-heavy projects remotely, albeit with some limitations.
Simulations, in particular, were beneficial. They allowed the researcher to test a large number of conditions in a short period of time, a luxury not always available in a traditional lab setting. However, discussions with advisers and other lab members ensured that the data remained applicable to the project.
Collaboration is a crucial aspect of scientific research, and this remains true in the realm of remote research. Sharing data and software for further research purposes is common, with lab members often willing to help each other out. Access to sample data from other researchers can be particularly beneficial for remote lab work.
To conduct laboratory research remotely effectively, several strategies can be employed. Leveraging advanced imaging and AI tools, for instance, can help perform experiments and interpret results without a constant physical presence in the lab. Engineered tissue models compatible with remote manipulation can also be used, such as organoids and 3D bioprinted constructs.
Virtual and remote laboratories, including virtual microscopes and remotely operated instruments, can be engaged with to conduct experiments and collect data remotely. Maintaining comprehensive and digital documentation using electronic lab notebooks and cloud-based collaboration tools can also help record procedures, share data, and coordinate research activities efficiently.
Strong communication and coordination protocols, such as regular virtual meetings, clear task assignments, and remote mentorship, can help maintain research progress and troubleshoot issues despite the distance. Adopting automation and IoT solutions, such as wearable and intelligent biomedical systems, automated experimental setups, and IoT-enabled sensors, can provide real-time monitoring and control of experiments from afar.
These strategies allow bioengineering researchers to overcome challenges of distance and limited lab access by combining cutting-edge technology, virtual tools, and robust digital workflows tailored to the complexity of biomedical experiments. While remote research may have its limitations, it is a valuable tool in the modern scientific landscape, particularly during times of crisis like the ongoing pandemic.
[1] Leveraging advanced imaging and AI tools: [URL] [2] Using biomimetic and organoid models compatible with remote manipulation: [URL] [3] Implementing virtual and remote laboratories: [URL] [4] Maintaining comprehensive and digital documentation: [URL] [5] Developing strong communication and coordination protocols: [URL] [6] Adopting automation and IoT solutions: [URL]
- Despite the challenges, independent work on the junior paper in the field of science, specifically investigating DNA damage in persister subpopulations of E.Coli cells, was facilitated by the researcher's use of MATLAB programs and simulations, even when conducting research remotely due to the COVID-19 pandemic.
- To address medical-conditions related to the pandemic, health-and-wellness researchers could benefit from collaborating and sharing data, and using advanced technology such as AI tools, virtual laboratories, and engineered tissue models compatible with remote manipulation, as demonstrated by the Princeton University researcher.
- To ensure the accuracy and relevancy of their research findings, the researcher also engaged in regular discussions with advisers and other lab members, demonstrating the importance of strong communication and coordination protocols during remote work, particularly in the realm of science and technology.
