Sussex Scientists Unveil Structure of Vital Cell Energy Regulator
A team led by Olivier Boulon from the University of Sussex has determined the structure of a crucial nanomachine, the R2TP-TTT, which plays a vital role in assembling mTORC1, a key regulator of cell energy metabolism. The findings were published in Cell Reports on July 6th, with a DOI of 10.1016/j.celrep.2021.109317.
The research, funded by the BBSRC and The Welcome Trust, used state-of-the-art cryo-electron microscopy. The new image reveals how the TTT proteins control the R2TP machine, keeping components of mTORC1 ready for assembly. This molecular chaperone function is crucial for the proper functioning of mTORC1, which in turn regulates the cell's energy metabolism.
The University of Sussex has recently invested in a cutting-edge cryo-electron microscope, enabling such detailed research. The R2TP-TTT nanomachine's structure determination is a significant step forward in understanding its role in human cell biology.
The research, published in Cell Reports, sheds light on the structure and function of the R2TP-TTT nanomachine. Understanding this molecular chaperone's role in mTORC1 assembly could pave the way for future research into cell energy metabolism regulation and related diseases.
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