Introduction
Interactions of Latuda with Alcohol, Supplements, and Other Substances
Lurasidone, sold under the brand name Latuda, is a prescription medication used to manage symptoms of schizophrenia and depressive episodes linked to bipolar disorder in adults and certain children. Like other medicines, Latuda can interact with certain drugs, supplements, and foods. An interaction occurs when one substance alters the effects of another.
For more information about Latuda's interactions, keep reading. For additional details on its uses, check out this article.
When to Avoid Latuda
Certain factors or health conditions may prevent your doctor from prescribing Latuda due to potential harm. These are known as contraindications. Latuda's contraindications include:
Drug type or drug name
Using medications called strong CYP3A4 blockers
Drug examples
Latuda is processed by an enzyme called CYP3A4. Some medications called strong CYP3A4 blockers may interfere with this enzyme, causing Latuda levels to increase, which can enhance side effects.
Interaction result with Latuda
Your doctor or pharmacist will usually refrain from prescribing Latuda if you're taking a strong CYP3A4 blocker.
Examples of strong CYP3A4 blockers include:
strong CYP3A4 blockers*
- ketoconazole (Nizoral)
- clarithromycin
- ritonavir (Norvir)
- voriconazole (Vfend)
• ketoconazole (Nizoral)• clarithromycin• ritonavir (Norvir)• voriconazole (Vfend)
If you're currently using a strong CYP3A4 blocker, inform your doctor before starting Latuda treatment. They can assist you in selecting the appropriate treatment plan.
can increase the risk of side effects from Latuda†
Using medications called strong CYP3A4 inducers
Latuda is processed by an enzyme called CYP3A4. Some substances called strong CYP3A4 inducers may cause this enzyme to speed up, decreasing Latuda levels and reducing its effectiveness.
moderate CYP3A4 blockers
Doctors usually won't prescribe Latuda when it's used in combination with a strong CYP3A4 inducer.
• diltiazem (Cardizem CD)• atazanavir (Reyataz)• erythromycin (Eryc)• fluconazole (Diflucan)• verapamil (Verelan)• fluoxetine (Prozac)
If you're uncertain whether you're using any strong CYP3A4 inducers, consult your doctor or pharmacist. Examples of strong CYP3A4 inducers include:
can increase the risk of side effects from Latuda†
- rifampin (Rimactane)
- St. John’s wort
- phenytoin (Dilantin)
- carbamazepine (Tegretol)
If you're taking a strong CYP3A4 inducer, inform your doctor before starting Latuda treatment. They can advise you on a suitable treatment plan.
strong CYP3A4 inducers*
Having had an allergic reaction to Latuda or its components
• rifampin (Rimactane)• phenytoin (Dilantin)• carbamazepine (Tegretol)
If you've had an allergic reaction to Latuda or any of its ingredients, your doctor may choose not to prescribe it, as it could cause another allergic reaction. You can discuss alternative treatments with them.
can decrease the effectiveness of Latuda
Note: It's essential to inform your doctor if any of these contraindications apply to you before starting Latuda treatment. They can evaluate whether to prescribe Latuda and may suggest alternative options if necessary.
Latuda and Alcohol
moderate CYP3A4 inducers
While there isn't any known interaction between Latuda and alcohol, both substances can cause similar side effects. Drinking alcohol during Latuda treatment could increase the risk of these side effects.
• bosentan (Tracleer)• efavirenz (Sustiva)• etravirine (Intelence)• modafinil (Provigil)• nafcillin
Both Latuda and alcohol can lead to:
can decrease the effectiveness of Latuda
- drowsiness
- nausea
- vomiting
- slow movements
If you would like to drink alcohol while taking Latuda, speak with your doctor about safe alcohol consumption amounts for you.
opioids
Latuda Interactions with Other Medications
• fentanyl (Fentora)• tramadol (Conzip)• oxycodone (Roxicodone)
Before taking Latuda, share details about your current prescription, over-the-counter, and other medications with your doctor and pharmacist. Sharing this information can help prevent potential interactions.
can increase the risk of side effects from Latuda† and opioids
If you have questions regarding drug interactions that may affect you, consult with your doctor or pharmacist.
Here's a chart of medications that can interact with Latuda. Keep in mind that this chart does not include all possible drugs that may interact with Latuda. Some of these interactions are described in greater detail below in "In-depth Drug Interactions."
antihistamines
| | | || --- | --- | --- || Drug type or drug name | Drug examples | Interaction result with Latuda || strong CYP3A4 blockers* | • ketoconazole (Nizoral)• clarithromycin• ritonavir (Norvir)• voriconazole (Vfend) | might amplify Latuda's side effects || moderate CYP3A4 blockers | • diltiazem (Cardizem CD)• atazanavir (Reyataz)• erythromycin (Eryc)• fluconazole (Diflucan)• verapamil (Verelan)• fluoxetine (Prozac) | may enhance Latuda's side effects || strong CYP3A4 inducers* | • rifampin (Rimactane)• phenytoin (Dilantin)• carbamazepine (Tegretol) | might reduce Latuda's effectiveness || moderate CYP3A4 inducers | • bosentan (Tracleer)• efavirenz (Sustiva)• etravirine (Intelence)• modafinil (Provigil)• nafcillin | could diminish Latuda's effectiveness || opioids | • fentanyl (Fentora)• tramadol (Conzip)• oxycodone (Roxicodone) | might boost Latuda's side effects and those of opioids || antihistamines | • diphenhydramine (Benadryl)• hydroxyzine (Vistaril)• doxylamine (Unisom) | may amplify Latuda's side effects and that of antihistamines || blood pressure medications | • amlodipine (Norvasc)• carvedilol (Coreg)• losartan (Cozaar)• lisinopril (Zestril) | might enhance Latuda's side effects and those of blood pressure medications || benzodiazepines | • alprazolam (Xanax)• clonazepam (Klonopin)• lorazepam (Ativan) | could amplify Latuda's side effects and those of benzodiazepines || certain stimulant drugs | • lisdexamfetamine (Vyvanse)• amphetamine salts (Adderall) | may reduce both Latuda's and stimulant drugs' effectiveness || other antipsychotics | • cariprazine (Vraylar)• aripiprazole (Abilify)• haloperidol (Haldol) | might amplify Latuda's side effects and those of other antipsychotics || sedatives or hypnotics | • zolpidem (Ambien)• suvorexant (Belsomra)• eszopiclone (Lunesta) | could boost Latuda's side effects and those of sedatives or hypnotics || bupropion (Wellbutrin SR) | — | might heighten Latuda's side effects and those of bupropion |
• diphenhydramine (Benadryl)• hydroxyzine (Vistaril)• doxylamine (Unisom)
Detailed drug interactions with Latuda
can increase the risk of side effects from Latuda† and antihistamines
Here's a more detailed account of some interactions with Latuda.
Benzodiazepines
blood pressure medications
Benzodiazepines are commonly used to treat anxiety and/or seizure disorders.
• amlodipine (Norvasc)• carvedilol (Coreg)• losartan (Cozaar)• lisinopril (Zestril)
Results of interaction. Using both benzodiazepines and Latuda at once may raise the chance of side effects from both drugs, such as breathing issues and low blood pressure. (For more info about Latuda's side effects, refer to this article.)
can increase the risk of side effects from Latuda† and blood pressure medications
Explanation of interaction. Both Latuda and benzodiazepines can have an impact on the central nervous system. This could result in side effects like a slower breathing rate, low blood pressure, and drowsiness. Taking these drugs together could raise your risk of these side effects further.
Benzodiazepine examples. Some potential benzodiazepines that can interact with Latuda are:
benzodiazepines
- alprazolam (Xanax)
- clonazepam (Klonopin)
- lorazepam (Ativan)
• alprazolam (Xanax)• clonazepam (Klonopin)• lorazepam (Ativan)
Actions by you or your doctor. Before starting Latuda treatment, let your doctor know if you're currently on any benzodiazepines. They can assess the safety of combining these drugs.
can increase the risk of side effects from Latuda† and benzodiazepines
If your doctor does prescribe Latuda with a benzodiazepine, they'll likely monitor you more closely than usually. Depending on the situation, they might even suggest a different treatment option.
Guidelines for Integrating Latuda with Other Medications. If you're taking bupropion, inform your doctor before beginning Latuda treatment. They can assess if it's safe for you to use both drugs simultaneously.
certain stimulant drugs
If your doctor prescribes Latuda along with bupropion, they might initiate your bupropion treatment at a lower dose. Over time, they might incrementally raise the dose to allow your body to adapt to the medication. Throughout your treatment, your doctor will monitor you closely for any side effects.
• lisdexamfetamine (Vyvanse)• amphetamine salts (Adderall)
Other Antipsychotics
can decrease the effectiveness of both Latuda and stimulant drugs
Antipsychotics are commonly used to address conditions like schizophrenia or bipolar disorder. Latuda is itself a type of antipsychotic.
Interaction Outcome. Co-administration of Latuda with other antipsychotics may augment the likelihood of side effects from both medications. These include drowsiness or involuntary movements. (For additional details about Latuda's side effects, consult this resource.)
other antipsychotics
Interaction Explanation. Both Latuda and other antipsychotics can induce side effects such as somnolence or involuntary movements. The combination of these drugs could heighten the risk of these side effects further.
• cariprazine (Vraylar)• aripiprazole (Abilify)• haloperidol (Haldol)
List of Other Antipsychotic Medications. The following antipsychotics might interact with Latuda:
can increase the risk of side effects from Latuda† and other antipsychotics
- cariprazine (Vraylar)
- aripiprazole (Abilify)
- haloperidol (Haldol)
Guidelines for Using Latuda with Other Antipsychotics. Prior to taking Latuda, advise your doctor if you're using any other antipsychotics. They can offer guidance on whether this combination is safe for you.
sedatives or hypnotics
If your condition necessitates the use of multiple antipsychotics, your doctor may keep a closer watch for side effects or adjust your dosages accordingly. Establish a dialogue with your doctor to determine the optimal treatment plan for you.
• zolpidem (Ambien)• suvorexant (Belsomra)• eszopiclone (Lunesta)
Latuda and Other Interactions
can increase the risk of side effects from Latuda† and sedatives or hypnotics
Latuda might interact with supplements, foods, vaccines, or even lab tests. Below, you'll find further details about these interactions. Please remember that this information does not encompass all possible interactions with Latuda.
Latuda and Supplement Interactions
bupropion (Wellbutrin SR)
Before starting Latuda treatment, share information about your supplements, herbs, and vitamins with your doctor and pharmacist. This might help prevent potential interactions.
—
If you have concerns about drug interactions affecting you, consult your doctor or pharmacist.
can increase the risk of side effects from Latuda† and bupropion
Latuda and Herb Interactions
Doctors will typically advise against taking St. John's wort with Latuda. St. John's wort is an herb occasionally employed to alleviate depression.
Latuda may interact with St. John's wort. Latuda is metabolized by an enzyme called CYP3A4. St. John's wort may stimulate this enzyme to work more rapidly than usual. Consequently, the concentration of Latuda in your body might drop, rendering it less effective.
If you have questions about using certain herbs with Latuda, engage with your doctor.
Latuda and Vitamin Interactions
There are no documented reports of vitamins interacting with Latuda. However, potential vitamin interactions could be identified in the future. Speak with your doctor or pharmacist before using any vitamin product with Latuda.
Latuda and Food Interactions
Latuda could interact with grapefruit and grapefruit juice. In fact, doctors usually advise against consuming grapefruit or grapefruit juice while taking Latuda.
Latuda is metabolized by an enzyme called CYP3A4. Grapefruit and grapefruit juice can inhibit this enzyme, resulting in an accumulation of Latuda in your system, thereby increasing your risk of side effects. (For additional details about Latuda's side effects, consult this resource.)
If you have questions about which foods are compatible with Latuda, communicate with your doctor or pharmacist.
Latuda and Vaccine Interactions
There aren't any known interactions between Latuda and vaccines. Your doctor or pharmacist can provide information about any necessary vaccines.
Latuda and Lab Test Interactions
There are no known interactions between Latuda and lab tests. If you have any queries, speak with your doctor.
*LATUDA INTERACTION WITH CANNABIS OR CBDCannabis* (often referred to as marijuana) and cannabis products, such as cannabidiol (CBD**), have been observed to interact with Latuda. Cannabis can cause elevated or reduced levels of Latuda in your body. This can amplify the risk of side effects from Latuda or reduce its effectiveness.
Before initiating Latuda treatment, inform your doctor and pharmacist if you use cannabis. Sharing this information may help prevent potential interactions.
Note: Cannabis is illegal at a federal level but is legal in many U.S. states to varying degrees.
- Emotional states, like suicidal thoughts or actions. There's a chance that using Latuda could boost the chance of experiencing suicidal thoughts and behaviors in individuals, particularly the youth who are under depression medication prescription.* (Latuda is employed for treating depression.) Individuals aged 24 years or younger might have an enhanced risk of experiencing this side effect. Prior to commencing Latuda therapy, inform your physician if you've ever had unpleasant emotional states or suicidal thoughts or behaviors.
- Senior adults with psychosis resulting from dementia. Latuda could increase the chance of mortality in older adults (65 years and above) who deal with psychosis due to dementia.* This risk is specific to this age group of adults who ingest antipsychotic medications, such as Latuda. If you are a senior adult with psychosis related to dementia, your doctor might suggest an alternative approach for you.
- Heart issues. Disclose to your doctor if you have heart problems or if you've ever had a stroke. Antipsychotic medications, like Latuda, can amplify the risk of heart problems or stroke. If you have endured such conditions, Latuda may exacerbate them. In such situations, your doctor can decide if Latuda might be secure for you.
- Blood pressure concerns. If you have elevated or decreased blood pressure, notify your doctor before using Latuda. This medication can provoke high or low blood pressure. If you already have one of these conditions, Latuda might worsen them. Your physician can help ascertain if Latuda may be suitable for you.
- Diabetes. Prior to starting Latuda therapy, share with your doctor if you have diabetes or high blood sugar. It's possible for antipsychotic medications, like Latuda, to augment your blood sugar. If you currently have diabetes or high blood sugar, Latuda may exacerbate them. In this case, your physician might advise monitoring your blood sugar more frequently throughout your treatment.
- High cholesterol or triglycerides. If you have high cholesterol or triglycerides, discuss the matter with your doctor before using Latuda. Latuda can boost your cholesterol or triglyceride levels. If you already have high cholesterol or triglyceride levels, Latuda may raise them even further. In such cases, your physician might monitor your levels using blood tests more frequently than usually.
- High prolactin levels. It's possible for Latuda to elevate the levels of a hormone called prolactin. If you already have high prolactin levels, using Latuda could worsen your condition. In such cases, your physician can help ascertain if Latuda is appropriate for you.
- Low white blood cell levels. If you have low white blood cell levels, inform your doctor prior to using Latuda. This medication may precipitate low white blood cell levels. If you already have low levels, Latuda may decrease them even further. Your doctor might monitor your blood cell levels throughout your treatment. In certain instances, they might suggest an alternative drug for you.
- Seizures. The risk of seizures could potentially increase with the use of Latuda. If you've previously had seizures, using Latuda might heighten the risk even further. In such cases, your physician can help ascertain if Latuda is a secure treatment option for you.
- Kidney issues. In uncommon instances, Latuda could cause kidney problems. Prior to initiating Latuda treatment, inform your doctor about any kidney problems you have. Your physician can help ascertain if Latuda is appropriate for you. In such cases, they might adjust your dose of Latuda.†
- Liver issues. If you have a liver problem, talk to your physician before using Latuda. Certain liver conditions may impact how your body responds to the medication. In such cases, your physician might diminish your dose of Latuda.† They'll prescribe the suitable dose of Latuda for you.
- Parkinson's disease or Lewy body dementia. Inform your doctor if you have Parkinson's disease or Lewy body dementia. If you have either of these conditions and use Latuda, you might have an increased risk of side effects from the drug. Your physician might monitor you more frequently than usual or recommend an alternative treatment option for you.
- Pregnancy. It is undetermined if Latuda is secure for use during pregnancy. If you are pregnant or planning to get pregnant, speak to your doctor prior to using Latuda.‡
- Breastfeeding. It is unclear if Latuda is secure to use while breastfeeding. If you are breastfeeding or considering it, discuss the matter with your doctor before commencing Latuda treatment.
- Allergic reactions. If you have experienced an allergic reaction to Latuda or any of its components, your physician probably won't prescribe Latuda. To learn more, see “When to avoid Latuda” above.
Assistance is accessible
If you or someone you know is in crisis and contemplating suicide or self-harm, please seek help:
- Call or text the 988 Lifeline at 988 or chat at 988lifeline.org. Supportive counselors are available to listen and provide free and confidential support 24/7.
- Text HOME to the Crisis Text Line at 741741 to connect with a volunteer crisis counselor for free and confidential support 24/7.
- Not in the United States? Find a helpline in your country with Befrienders Worldwide.
- Call 911 or your local emergency services number if you feel safe to do so.
If you're acting on someone else's behalf, stick with them until help arrives. You can safely remove weapons or harmful substances if it's feasible.
If you're not residing in the same household, keep the phone line open with them until help arrives.
FAQs regarding Latuda and its interactions
Here are some commonly asked questions about Latuda and potential interactions.
Can I use Latuda alongside over-the-counter pain medicines like ibuprofen?
Generally, Latuda can be used with over-the-counter (OTC) pain medicines such as ibuprofen (Advil, Motrin). Other OTC pain medications could include naproxen (Aleve) and acetaminophen (Tylenol).
However, be mindful of other pain medications such as opioid drugs, as they might interact with Latuda. (Gain more insights by checking the “Latuda's interactions with other medications” section above.)
Discuss your medication choices with your doctor or pharmacist to establish safe options.
Which antidepressants are compatible with Latuda and don't interact with it?
The use of certain antidepressants with Latuda should be relatively safe. Antidepressants, prescription medications designed to treat depression, may not interact with Latuda. For instance, there's no identified interaction between Latuda and the following antidepressants:
- venlafaxine (Effexor XR)
- escitalopram (Lexapro)
- duloxetine (Cymbalta)
However, one should be cautious about the potential interactions between Latuda and other antidepressants, such as fluoxetine (Prozac). (Visit the “Latuda's interactions with other medications” section for further details.)
Your doctor can offer insights regarding potential interactions between antidepressants and Latuda.
If your doctor prescribes an antidepressant while you're taking Latuda, they can suggest compatible options for you.
Does Latuda interact with Lamictal?
Latuda isn't known to interact with lamotrigine (Lamictal). Lamotrigine is a drug used for treating seizure disorders or bipolar disorder. Latuda should generally be safe when combined with lamotrigine.
Contact your doctor or pharmacist if you have queries about combining Latuda and lamotrigine.
Preventing interactions
To minimize potential interactions with Latuda, take the following precautions:
- Consult your doctor and pharmacist before beginning treatment.
- Disclose your alcohol and cannabis consumption.
- Share information on all other medications, supplements, herbs, and vitamins.
- Create a medication list, which can be filled out by your doctor and pharmacist.
Read the Latuda label and other printed materials for safety warnings. These materials may include colored stickers that highlight an interaction. Also, refer to the included medication guide or patient package insert, which may contain interaction details. If Latuda doesn't come with such information, ask your pharmacist to print a copy. If you have questions about this information, consult your doctor or pharmacist.
Lastly, adhere strictly to your doctor's dosage instructions for Latuda.
Additional Resources
Beyond learning about interactions, you might be interested in other Latuda-related topics. These resources might help:
- Latuda Overview. For an overall understanding of Latuda, see this article.
- Side Effects. If you're curious about Latuda's side effects, consult this article. Alternatively, refer to the Latuda prescribing information.
- Dosage Details. To learn about Latuda's dosage, check out this article.
- Drug Comparison. Find information about Latuda compared to Abilify, Vraylar, and Seroquel.
- Facts about Your Condition. To learn more about your condition, explore our depression hub, bipolar disorder hub, and mental health hub.
Disclaimer: Medical News Today has made every effort to ensure that all information is factually correct, comprehensive, and up to date. However, use this article as an informational tool and not as a substitute for professional medical advice. Always consult your doctor or pharmacist before beginning any medication. The drug information included in this article is subject to change and should not be considered all-encompassing or necessarily applicable to all individuals. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.
- If you're currently using a strong CYP3A4 blocker such as ketoconazole (Nizoral), clarithromycin, ritonavir (Norvir), or voriconazole (Vfend), inform your doctor before starting Latuda treatment to discuss an appropriate treatment plan.
- Consuming alcohol during Latuda treatment could increase the risk of side effects such as drowsiness, nausea, vomiting, and slow movements, so it's a good idea to consult your doctor about safe alcohol consumption amounts.
- Certain mental health conditions, like bipolar disorder, might require medications such as strong CYP3A4 inducers like rifampin (Rimactane), St. John’s wort, phenytoin (Dilantin), or carbamazepine (Tegretol), which can interact with Latuda, increasing the risk of side effects or decreasing its effectiveness. It's essential to inform your doctor about all your current medications before starting Latuda treatment.
