Interactions Detailed: Alcohol Consumption, Supplement Usage, and Beyond (Regarding Camzyos)
Camzyos (mavacamten) is a mind-blowing oral capsule used for treating that troublesome heart condition called obstructive hypertrophic cardiomyopathy. But it ain't a one-man show, this little pill interacts with some other substances, causing unforeseen consequences.
Got a handle on what an interaction is? It occurs when a substance fucks with another substance's effect, typically due to a combo of meds or a supplement and Camzyos.
Interested in learning more about Camzyos's encounters with other medications? Keep it locked.
Camzyos meets other meds
Camzyos, those cytochrome P450 (CYP) enzymes' wingman, can dance with drugs that mess with these enzymes' action. Specifically, CYP3A4 and CYP2C19. These enzymes aid in Camzyos's departure from your body, but when you got meds that inhibit (reduce) or induce (increase) their action, things can get messy.
Wanna know how you can prevent potential interactions? Let your doc and pharmacist know about every prescription, over-the-counter, and other drug you're taking. Sharing that info can help avoid any unexpected dances.
strong CYP3A4 inhibitors*
Here's a table of some drugs that play story with Camzyos:
• clarithromycin• itraconazole (Sporanox)• ritonavir (Norvir)• nefazodone
| Drug group/name | Drug examples | Interaction result with Camzyos ||-------------------------------|---------------------------|----------------------------------|| Super inhibitors | clarithromycin, itraconazole, ritonavir, nefazodone | Up the risk of Camzyos's side effects || Inhibitors (strong/moderate) | cimetidine, esomeprazole, fluconazole, fluoxetine | Up the risk of side effects || Inhibitors* (moderate) | amiodarone, ciprofloxacin, erythromycin, danazol | Up the risk of side effects || Weak inhibitors | nicardipine, omprazole, oxcarbazepine | Up the risk of side effects || Certain heart medications | beta-blockers, diltiazem, disopyramide, verapamil | Up the risk of side effects from Camzyos || Combined birth control pills | ethinyl estradiol/desogestrel, ethinyl estradiol/drospirenone | Make combined birth control pills less effective || Drugs broken down by CYP3A4, CYP2C19, and CYP2C9 | glipizide, midazolam, repaglinide | Make these drugs less effective |
can increase the risk of side effects of Camzyos
When to avoid Camzyos
In some cases, factors or conditions could prevent your doc from prescribing Camzyos due to potential risks. These are called contraindications. Camzyos's got 'em, and here are the biggies:
strong or moderate CYP2C19 inhibitors*
Taking drugs affecting CYP enzymes
• cimetidine (Tagamet HB)• esomeprazole (Nexium)• fluconazole (Diflucan)• fluoxetine (Prozac)
Docs typically won't prescribe Camzyos if you're takin' those meds that mess with specific CYP enzymes in your bod.
can increase the risk of side effects of Camzyos
Specifically, they'll steer clear of prescribing Camzyos with certain drugs that inhibit (reduce the action of) two enzymes: CYP3A4 and CYP2C19. Inhibiting these enzymes can make Camzyos build up in your body, increasing the risk of side effects, such as heart failure.
Trying to kick the shit out of Camzyos with strong/moderate CYP2C19 inhibitors or strong CYP3A4 inhibitors can heighten the chance of severe side effects like heart failure. Examples include certain seizure meds, antifungals, HIV drugs, antidepressants, and more.
strong or moderate CYP3A4 inducers*
Don't forget that Camzyos plays a dangerous dance when combined with drugs that induce (increase the action of) CYP3A4 or CYP2C19. By making Camzyos less effective, it can "tone it down," reducing the ability to treat heart conditions.
• carbamazepine (Tegretol, others)• phenytoin (Dilantin)• rifampin (Rifadin, Rimactane)
Having had an allergic reaction to Camzyos
can make Camzyos less effective
If you've had an allergic reaction to Camzyos or its ingredients, your doc will likely refuse to prescribe Camzyos. Attempting to take the drug could trigger another allergic reaction. Chat with 'em about alternative treatments, just in case.
Camzyos meets alcohol
strong or moderate CYP2C19 inducers*
There aren't any known interactions between Camzyos and alcohol. However, your doc can advise you to steer clear or limit alcohol consumption during Camzyos treatment. This is because drinking alcohol while taking the drug could worsen some of Camzyos's side effects, like dizziness.
• apalutamide (Erleada)• efavirenz• enzalutamide (Xtandi)
Interactions in-depth
can make Camzyos less effective
Wanna get to the nitty-gritty of Camzyos's drug interactions? Let's dive deeper.
Certain heart medications
moderate CYP3A4 inhibitors
Camzyos may twist tango with certain heart medications that slow or weaken your heartbeat. Meds used to treat angina, irregular heartbeats, and high blood pressure may fall under this category.
• amiodarone (Pacerone)• ciprofloxacin (Cipro)• erythromycin (Erytab, others)• danazol
Interaction result: Taking Camzyos with these heart medications can raise your risk of heart failure with Camzyos.
can increase the risk of side effects of Camzyos
Explanation: Camzyos loosens up your heart muscle, potentially causing heart failure in some people. Combining it with medications that slow or weaken your heartbeat can weaken it even more, increasing the risk of heart failure with Camzyos.
Examples of these heart medications include beta-blockers, diltiazem, disopyramide, ranolazine, and verapamil.
weak CYP2C19 inhibitors
What you or your doc might do: Your doc will likely decide against prescribing Camzyos if you're already taking diltiazem or verapamil with a beta-blocker. They may also steer clear of prescribing Camzyos if you're taking disopyramide or ranolazine.
• nicardipine• omeprazole (Prilosec) • oxcarbazepine (Trileptal)
If your doc prescribes Camzyos along with diltiazem, verapamil, or a beta-blocker on its own, they'll likely monitor your heart closely. Inform your doc right away if you experience heart failure symptoms, such as shortness of breath, swelling in your lower legs or feet, fatigue, or chest pain.
can increase the risk of side effects of Camzyos
If you got questions about taking Camzyos with other heart medications, hit up your doc or pharmacist.
Combined birth control pills
certain heart medications
Combined birth control pills contain estrogen and progestogen hormones, used to prevent pregnancy.
• beta-blockers, such as metoprolol (Lopressor)• diltiazem (Cardizem CD, others)• disopyramide (Norpace)• ranolazine (Aspruzyo sprinkle)• verapamil (Verelan)
Interaction result: Camzyos can make birth control pills less effective.
can increase the risk of side effects of Camzyos
Explanation: Camzyos can increase the action of the enzyme CYP3A4, which helps break down the hormones in combined birth control pills. By increasing the action of CYP3A4, Camzyos can decrease the levels of these hormones in your body, making them less effective at preventing pregnancy.
Examples of combined birth control pills that may interact with Camzyos include ethinyl estradiol/desogestrel, ethinyl estradiol/drospirenone, ethinyl estradiol/ethynodiol diacetate, and ethinyl estradiol/levonorgestrel.
combined birth control pills
What you or your doc might do: If you're able to get pregnant and plan to, your doc will likely recommend an alternative form of contraception during Camzyos treatment. (Remember that Camzyos can cause fetal harm, so it's essential to use an effective form of birth control to avoid getting pregnant during Camzyos treatment.)
• ethinyl estradiol/desogestrel (Cyclessa, others)• ethinyl estradiol/drospirenone (Yaz)
If you take Camzyos with a birth control pill, your doctor may recommend using a nonhormonal form of birth control, like condoms, as well. Consider using additional birth control while taking Camzyos and for 4 months after quitting Camzyos.
can make combined birth control pills less effective
If you have questions about taking Camzyos with birth control, chat with your doc or pharmacist.
Camzyos and other interactions
drugs that are broken down by CYP3A4, CYP2C19, and CYP2C9
Camzyos could potentially interact with other things, like supplements, food, vaccines, or even lab tests. Here's additional info on supplement interactions. Like always, if you got questions, ask your doc or pharmacist.
• glipizide (Glucotrol XL)• midazolam (Nayzilam, Seizalam)• repaglinide
Camzyos interactions with supplements
can make drugs broken down by CYP3A4, CYP2C19, and CYP2C9 less effective
Before you start treatment with Camzyos, spill the beans to your doc and pharmacist about any supplements, herbs, or vitamins you're taking. Knowing this info can help you avoid potential interactions.
If you've been taking St. John's Wort, your doc may recommend against using it with Camzyos. St. John's Wort may speed up the activity of an enzyme in your body called CYP3A4, which helps metabolize Camzyos. Speeding up this enzyme can cause Camzyos to metabolize faster, potentially reducing the effectiveness of Camzyos.
When it comes to vitamins, there aren't any specific reports of vitamins interacting with Camzyos. However, that doesn't mean vitamin interactions won't pop up or be recognized in the future. Because of this, it's essential to consult with your doc or pharmacist before trying any vitamin product with Camzyos.
Camzyos and food
Grapefruit and grapefruit juice can have an impact on Camzyos. Specifically, grapefruit products can hinder your body's ability to break down Camzyos, leading to higher levels of Camzyos in your system and a greater chance of experiencing side effects from Camzyos. Due to this risk, your doc may advise you not to consume grapefruit or grapefruit juice while taking the drug.
Camzyos and vaccines
There aren't any known interactions between Camzyos and vaccines. Get in touch with your doc or pharmacist to see whether you need any vaccines.
Camzyos and lab tests
There aren't any known interactions between Camzyos and lab tests. If you've got concerns about this medication interfering with lab tests, talk with your doc.
Camzyos and cannabis/CBD
Cannabis (frequently called marijuana) and cannabis products, like CBD, haven't been specifically reported to interact with Camzyos. However, cannabis and cannabis products are known to affect enzymes in your body that aid in Camzyos's metabolism. It's possible that using cannabis while taking Camzyos could affect Camzyos's levels in your body. This could either increase your risk of Camzyos side effects or decrease Camzyos's effectiveness at treating HCM.
As always, consult your doc before using cannabis while taking Camzyos. The effects of cannabis may also impact how well you adhere to your Camzyos treatment plan.
Note: Cannabis is illegal at a federal level but is legal in numerous states to varying degrees.
Camzyos and health-related interactions
Certain medical conditions and factors might increase the risk of interactions with Camzyos. Talk with your doc about your health history before taking this drug, as Camzyos may not be the best treatment option if you got a few of these conditions or factors messing with your health.
Health conditions or factors that could interact with Camzyos include:
- Heart failure
- Serious infection
- Irregular heartbeat
- Allergic reaction
- Breastfeeding
- Pregnancy
Preventing interactions
You can take several steps to help avoid interactions with Camzyos. Reach out to your doc and pharmacist before starting treatment. Here's what you should plan to do:
- Let them know if you drink alcohol or use cannabis.
- Tell them about other medications, supplements, herbs, and vitamins you're taking.
- Have them help you fill out a .
It's important to read the Camzyos label and other information that may come with the drug. The label may display colored stickers mentioning an interaction, and the paperwork, sometimes referred to as the medication guide or patient package insert, may contain additional details about interactions.
If Camzyos doesn't come with paperwork, you can ask your pharmacist to print a copy. If you need assistance reading or understanding this information, ask your doc or pharmacist.
Lastly, always take Camzyos exactly as your doc prescribes.
- Some drugs that are broken down by cytochrome P450 (CYP) enzymes, specifically CYP3A4 and CYP2C19, may interact with Camzyos by affecting its departure from the body.
- If you're taking medications that are strong CYP3A4 inhibitors such as clarithromycin, itraconazole (Sporanox), ritonavir (Norvir), or nefazodone, it may increase the risk of Camzyos's side effects.
- Medications that are moderate CYP3A4 inhibitors like cimetidine, esomeprazole, fluconazole, fluoxetine can also potentially increase the risk of side effects with Camzyos.
- Warn your doctor or pharmacist of every prescription, over-the-counter, and other drug you're taking to help avoid potential drug interactions with Camzyos.
- Certain genetic factors, such as having variants in genes involved in drug metabolism like CYP2C19, might affect how Camzyos interacts with other medications, leading to increased risks of side effects. It's important to discuss your genetic background with your healthcare provider before starting treatment.
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