Conditions Linked: Ankylosing Spondylitis and Ehlers-Danlos Syndrome
Hey there! Ever heard of the connection between Ehlers-Danlos Syndrome (EDS) and Ankylosing Spondylitis (AS)? Let's explore this intriguing link and get a better understanding of these two conditions.
EDS, a rare genetic disorder, impacts connective tissue, while AS is a type of inflammatory arthritis primarily targeting the spine. Recent findings suggest a possible link between these conditions.
The Interplay between EDS and AS
Hypermobile EDS (HEDS), the most prevalent type of EDS, shows a connection with AS. The HLA-B27 gene, linked to AS, might increase the chances of developing this condition in people with HEDS.
A 2017 study looked into the number of individuals with HEDS who carried the HLA-B27 gene. The results showed that roughly one out of four individuals with HEDS tested positive for this gene, a rate higher than the 6.1% prevalence in the general population in the United States.
While not every person with the HLA-B27 gene will develop AS, they do have an increased risk. This association could indicate a connection between HEDS and AS.
Understanding EDS: Causes and Symptoms
EDS occurs due to mutations in genes responsible for collagen development. These mutations can come from one or both biological parents, or they might be the result of spontaneous mutations.
Health issues associated with EDS include:
- Joint pain
- Hypermobile joints
- Unstable joints
- Easy Bruising
- Extreme fatigue
- Rapid heart rate and dizziness following standing
- Heartburn
- Constipation
- Urinary incontinence
If someone with AS experiences these symptoms, they might also have EDS. However, these symptoms can be general and could be caused by other factors as well. Always consult a doctor for an accurate diagnosis if experiencing new or worsening symptoms.
Managing EDS and AS: Same Challenges, Different Treatments?
Currently, there is no specific cure for either AS or EDS. Doctors typically recommend managing symptoms through various treatment approaches. There are similarities in these management strategies, but treatments for the two conditions can vary.
Physical therapy, for instance, may help both EDS and AS patients achieve stronger joints, relieve or reduce pain, and avoid injuries. Other treatments might differ, though.
Treatments for EDS
In addition to physical therapy, treatments for managing EDS may include occupational therapy. An occupational therapist can assist individuals with EDS in managing their daily activities and provide advice on coping with their condition, as well as offer assistive equipment.
Some individuals with EDS might benefit from counseling and cognitive behavioral therapy (CBT).
Treatments for AS
Treatments for managing AS may include over-the-counter anti-inflammatory medications, biologic medications targeting immune messages, corticosteroids, janus kinase (JAK) inhibitors, and joint repair or replacement surgery, among others.
Other Conditions Associated with EDS
Besides AS, EDS might be connected to several other health issues such as orthostatic intolerance, dysregulation of the immune system, migraines, spinal instability, chronic pain, anxiety, and more.
Remember, this information is intended to provide insights into the possible link between EDS and AS. Always consult a healthcare professional for medical advice and guidance tailored to individual circumstances.
Stay curious and keep learning!
- People with Hypermobile Ehlers-Danlos Syndrome (HEDS), who carry the HLA-B27 gene, have a higher likelihood of developing Ankylosing Spondylitis (AS), a condition linked to this gene, as suggested by recent findings.
- While the HLA-B27 gene increases the risk of developing AS, not everyone who has this gene will actually develop the condition.
- In addition to AS, Ehlers-Danlos Syndrome (EDS) might be associated with other health issues such as orthostatic intolerance, migraines, spinal instability, chronic pain, anxiety, and more.
- Treatment strategies for managing both EDS and AS share similarities but can differ significantly, with physical therapy often being beneficial for both conditions, while other treatments may vary.
